Lasky-Su Research Group

Advancing scientific discovery through innovative research

About Our Group

Jessica Lasky-Su

Associate Professor in Medicine

Harvard Medical School

Associate Statistician

Brigham and Women's Hospital

Welcome to the Lasky-Su Research Group. Our team is dedicated to advancing scientific knowledge through innovative research and collaborative efforts at the intersection of omics, epidemiology, and statistical genetics.

Research Areas

Asthma, Allergy & Respiratory Disease

A primary focus for over 15 years, our group investigates the genetic, genomic, and metabolomic determinants of asthma severity and pathogenesis. Substantial NIH-funded projects are dedicated to a comprehensive characterization of asthma metabolomic profiles for clinical translatability, including the intricate interplay between genetics, metabolomics, and environmental exposures in early life that contribute to childhood asthma.

Latest Publications

Network analysis reveals protein modules associated with childhood respiratory diseases (Journal of Allergy and Clinical Immunology, 2025)
miRNAome-metabolome wide association study reveals effects of miRNA regulation in eosinophilia and airflow obstruction in childhood asthma (EBioMedicine, 2024)
Metabolite signatures associated with microRNA miR-143-3p serve as drivers of poor lung function trajectories in childhood asthma (EBioMedicine, 2024)
Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma (Nature Medicine, 2022)

Multi-Omic Aging Clock & Healthy Aging

Utilizing data from the Mass General Brigham Biobank, a key research initiative is the ambitious development of a 'multiomic aging clock'. This innovative work seeks to uncover the fundamental biological mechanisms of aging, aiming to identify biomarkers and pathways associated with healthy aging and age-related diseases through the powerful lens of integrated omics.

Neurodevelopmental & Mental Health

Our expertise extends to neurodevelopmental and mental health conditions. Foundational work applied statistical genetics to understand ADHD and bipolar disorder. More recently, our research includes significant contributions to understanding the genetic architecture of conditions like Lewy body dementia, building on a long history of neurological investigation.

Metabolic & Cardiovascular Conditions

We explore the metabolic underpinnings of widespread health challenges such as obesity, diabetes, and heart failure. By integrating metabolomics with other omics data, we aim to identify novel pathways and biomarkers that can lead to better prevention and treatment strategies for these critical metabolic diseases.

Diverse Disease Portfolio

The versatility of our integrative omics approach allows us to contribute to a wide array of fields. Our portfolio includes investigations into ocular diseases (age-related macular degeneration), various cancers, infectious processes like bacteremia, preeclampsia, and chronic liver disease, showcasing a broad and impactful research scope.